Long-Term Trends in Myocardial Infarction Incidence and Case Fatality in the National Heart, Lung, and Blood Institute’s Framingham Heart Study
Population
9,824 participants from the Framingham Heart Study, age 40 to 89 years, 54% women.
Design
Cohort
Follow-up
212,539 person-years
Authors
Discussion
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Member takes
Implication
Evolving AMI diagnostics likely mask true incidence declines and fatality improvements; leaves open accurate assessment of modern trends without standardized criteria.
Structured PICO
P
Population
9,824 participants from the Framingham Heart Study, age 40 to 89 years, 54% women.
O
Outcome
Annual incidence rates of first AMI (stratified by AMI-ECG vs AMI-marker) and 30-day, 1-year, and 5-year case fatality rates over 4 decades.hard clinical
The apparent stability in national AMI rates over 4 decades is likely due to a doubling of biomarker-diagnosed AMIs, which masks a 50% decline in ECG-diagnosed AMIs and a 60% reduction in case fatality.
Cite This Study
Parikh et al. (2009) studied this question.