Key result
Cardiorespiratory fitness was significantly correlated with exercise-induced changes in allopregnanolone (r = 0.89) and peak neuropeptide Y levels (r = 0.69), which in turn related to pain sensitivity.
Why the study?
Does cardiopulmonary exercise testing affect plasma neurohormone levels and pain sensitivity in trauma-exposed individuals with and without chronic pain/PTSD?
Observational (n=12)
No
Does cardiopulmonary exercise testing affect plasma neurohormone levels and pain sensitivity in trauma-exposed individuals with and without chronic pain/PTSD?
Effect estimate: r = 0.89
p-value: p=<0.001
Cardiorespiratory fitness is associated with higher plasma NPY levels and increased ALLO responses to exercise, which in turn relate to reduced pain sensitivity in trauma-exposed individuals.
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Hypothesis-generating for neurohormone-mediated exercise effects on pain in trauma-exposed individuals; leaves open whether fitness interventions alter these pathways.
Scioli‐Salter et al. (2016) conducted an observational in Chronic pain and posttraumatic stress disorder (PTSD) (n=12). Cardiopulmonary exercise testing (CPX) vs. Trauma-exposed healthy controls was evaluated on Correlation between peak VO2 and exercise-induced changes in allopregnanolone (ALLO) (r = 0.89, p=<0.001). Cardiorespiratory fitness was significantly correlated with exercise-induced changes in allopregnanolone (r = 0.89) and peak neuropeptide Y levels (r = 0.69), which in turn related to pain sensitivity.
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