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Determine the relation of body mass index and adult weight gain with the risk of developing clinical non-insulin-dependent diabetes in women.

September 1, 1990American Journal of Epidemiology

Weight as a Risk Factor for Clinical Diabetes in Women

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Determine the relation of body mass index and adult weight gain with the risk of developing clinical non-insulin-dependent diabetes in women.
Prospective cohort analysis of 113,861 US women aged 30–55 years without diagnosed diabetes at baseline in 1976.
Followed participants across 8 years (826,010 person-years) to identify incident cases of clinical non-insulin-dependent diabetes.
Evaluated diabetes risk across body mass index categories, weight at age 18, and adult weight change, adjusting for family history.
Identified 873 definite diabetes cases, with women at average body mass index (23.0–23.9 kg/m²) showing a relative risk of 3.6 compared to those under 22.0 kg/m².
Weight gain after age 18 was a major determinant of risk, conferring a relative risk of 11.3 for 20–35 kg gained and 17.3 for gains exceeding 35 kg.
The relationship between body mass index and diabetes was continuous, and adjustment for family history did not alter the elevated risk at average body mass index levels.

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Implication

Cohort study reveals continuous increase in diabetes risk with higher body mass index in women, indicating adult weight gain is a primary risk driver.

Cite This Study

Colditz et al. (1990) studied this question.

synapsesocial.com/papers/6a10b92aacd1dbe064644ea4 https://doi.org/10.1093/oxfordjournals.aje.a115686

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Implication

Cohort study reveals continuous increase in diabetes risk with higher body mass index in women, indicating adult weight gain is a primary risk driver.

Weight as a Risk Factor for Clinical Diabetes in Women

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Implication

Cite This Study

Weight as a Risk Factor for Clinical Diabetes in Women

Key Points

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Implication

Cite This Study

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