January 1, 2007Diabetic Medicine
How many cases of Type 2 diabetes mellitus are due to being overweight in middle age? Evidence from the Midspan prospective cohort studies using mention of diabetes mellitus on hospital discharge or death records
Key result
Overweight in middle age significantly increased the odds of developing diabetes mellitus compared to normal weight (OR 2.73; 95% CI 2.05-3.64).
Why the study?
Does being overweight or obese in middle age increase the risk of developing diabetes mellitus compared to normal weight?
Population
19,147 adults aged 45-64 years without reported diabetes mellitus at baseline.
Comparison
Overweight and obesity vs Normal weight (BMI 18.5 to < 25 kg/m²)
Design
Cohort
Follow-up
From screening in 1970-1976 to 31 March 2004
Authors
Discussion
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Member takes
Implication
Supports weight management counseling in middle age; leaves open causal confirmation via trials.
Study Design
Type
Cohort (n=19,147)
Multicenter
Yes
Structured PICO
Does being overweight or obese in middle age increase the risk of developing diabetes mellitus compared to normal weight?
P
Population
19,147 men and women aged 45-64 years without reported diabetes mellitus, followed from 1970-1976 to 2004.
E
Exposure
Overweight (BMI 25 to < 30 kg/m²) and obesity (BMI ≥ 30 kg/m²)
C
Comparator
Normal weight (BMI 18.5 to < 25 kg/m²)
O
Outcome
Development of diabetes mellitus identified from acute hospital discharge data and death certificateshard clinical
Main Result
Odds Ratio: 2.73 (95% CI 2.05–3.64)
Overweight and obesity in middle age are strongly associated with the development of diabetes mellitus, with an estimated 60% of cases potentially preventable if the population maintained normal weight.
Cite This Study
Hart et al. (2007) conducted a cohort in Diabetes mellitus (n=19,147). Overweight (BMI 25 to < 30 kg/m2) vs. Normal weight (BMI 18.5 to < 25 kg/m2) was evaluated on Development of diabetes mellitus (OR 2.73, 95% CI 2.05-3.64). Overweight in middle age significantly increased the odds of developing diabetes mellitus compared to normal weight (OR 2.73; 95% CI 2.05-3.64).