Key result
Pre-PCI pericoronary adipose tissue attenuation predicts ~11% higher odds of impaired global coronary flow reserve.
Why the study?
Impaired global coronary flow reserve is related to worse outcomes and inflammation is postulated to play a role in atherosclerosis, but the relationship between pre-procedural pericoronary adipose tissue inflammation and post-PCI global coronary flow reserve in first NSTE-ACS was unclear.
Does pre-procedural pericoronary adipose tissue attenuation predict impaired global coronary flow reserve after urgent percutaneous coronary intervention in patients with non-ST-segment-elevation acute coronary syndrome?
Population
116 first NSTE-ACS patients undergoing pre-PCI computed tomography angiography
Comparison
Patients with impaired g-CFR (<1.8) vs without impaired g-CFR
Design
Observational cohort study
Follow-up
1 month
Authors
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May identify higher-risk NSTE-ACS patients post-PCI; hypothesis-generating for perivascular inflammation in microvascular dysfunction.
Observational (n=116)
Does pre-procedural pericoronary adipose tissue attenuation predict impaired global coronary flow reserve after urgent percutaneous coronary intervention in patients with non-ST-segment-elevation acute coronary syndrome?
Effect estimate: OR 1.108 (95% CI 1.026-1.197)
p-value: p=0.009
Pre-procedural pericoronary adipose tissue attenuation on CT angiography is a significant predictor of impaired global coronary flow reserve 1 month after urgent PCI in NSTE-ACS patients, suggesting a link between perivascular inflammation and microvascular dysfunction.
Kanaji et al. (2020) conducted an observational in Non-ST-segment-elevation acute coronary syndrome (n=116). Pre-PCI pericoronary adipose tissue attenuation evaluated by CTA was evaluated on Impaired global coronary flow reserve (g-CFR <1.8) (OR 1.108, 95% CI 1.026-1.197, p=0.009). Mean pericoronary adipose tissue attenuation on pre-PCI computed tomography angiography independently predicted impaired global coronary flow reserve at 1 month (OR 1.108; 95% CI 1.026-1.197; P=0.009).
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