Key result
The accelerated k-t SENSE CMR sequence accurately quantified left ventricular ejection fraction with a bias of 2.4% compared to standard 2D-SSFP, while reducing acquisition time by nearly 60%.
Why the study?
To provide clinical validation of an accelerated k-t SENSE CMR sequence and investigate whether it accurately quantifies LV volumes, function, and mass compared to 2D-SSFP.
Does an accelerated k-t SENSE CMR sequence accurately quantify left ventricular volumes, function, and mass compared to standard 2D-SSFP in healthy volunteers and heart failure patients?
Cross-Sectional (n=42)
No
Does an accelerated k-t SENSE CMR sequence accurately quantify left ventricular volumes, function, and mass compared to standard 2D-SSFP in healthy volunteers and heart failure patients?
Accelerated k-t SENSE CMR is a clinically feasible alternative to standard 2D-SSFP for quantifying LV parameters, offering shorter acquisition times with good image quality.
OBJECTIVES: To provide clinical validation of a recent 2D SENSE-based accelerated cardiovascular magnetic resonance (CMR) sequence (accelerated k-t SENSE), investigating whether this technique accurately quantifies left ventricle (LV) volumes, function, and mass as compared to 2D cine steady-state free precession (2D-SSFP). METHODS: Healthy volunteers (n = 16) and consecutive heart failure patients (n = 26) were scanned using a 1.5 T MRI system. Two LV short axis (SA) stacks were acquired: (1) accelerated k-t SENSE (5-6 breath-holds; temporal/spatial resolution: 37 ms/1.82 × 1.87 mm; acceleration factor = 4) and (2) standard 2D-SSFP (10-12 breath-holds; temporal/spatial resolution: 49 ms/1.67 × 1.87 mm, parallel imaging). Ascending aorta phase-contrast was performed on all volunteers as a reference to compare LV stroke volumes (LVSV) and validate the sequences. An image quality score for SA images was used, with lower scores indicating better quality (from 0 to 18). RESULTS: ) for LV ejection fraction, end-diastolic volume index, end-systolic volume index, and mass index, respectively. LVSV by accelerated k-t SENSE presented good agreement with aortic flow. Interobserver and intraobserver variabilities for all LV parameters were also high. CONCLUSION: The accelerated k-t SENSE CMR sequence is clinically feasible and accurately quantifies LV volumes, function, and mass, with short acquisition time and good image quality.
No takes yet. Share an insight, caveat, or question.
Assuncao-Jr et al. (2019) conducted a cross-sectional in Heart failure (n=42). Accelerated k-t SENSE CMR sequence vs. Standard 2D-SSFP CMR sequence was evaluated on Left ventricular ejection fraction (LVEF) agreement (Bias 2.4%, 95% CI -5.4% to 10.1%). The accelerated k-t SENSE CMR sequence accurately quantified left ventricular ejection fraction with a bias of 2.4% compared to standard 2D-SSFP, while reducing acquisition time by nearly 60%.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: