Key result
Single-breath-hold 3D k-t BLAST cine MRI significantly underestimated left ventricular ejection fraction compared to 2D cine MRI (43% vs 48%, p<0.01), though the methods showed excellent correlation.
Why the study?
Does single-breath-hold 3D-cine b-SSFP provide comparable assessment of left ventricular function and mass compared to multiple-breath-hold 2D-cine b-SSFP in patients with cardiac diseases?
Cross-Sectional (n=46)
No
Does single-breath-hold 3D-cine b-SSFP provide comparable assessment of left ventricular function and mass compared to multiple-breath-hold 2D-cine b-SSFP in patients with cardiac diseases?
Absolute Event Rate: 43% vs 48%
p-value: p=<0.01
Single-breath-hold 3D-cine b-SSFP is a feasible alternative to 2D-cine for LV EF assessment, offering significantly shorter imaging times despite slight differences in absolute volume measurements.
OBJECTIVE: To assess the feasibility of single-breath-hold three-dimensional cine b-SSFP (balanced steady-state free precession gradient echo) sequence (3D-cine), accelerated with k-t BLAST (broad-use linear acquisition speed-up technique), compared with multiple-breath-hold 2D cine b-SSFP (2D-cine) sequence for assessment of left ventricular (LV) function. METHODS: Imaging was performed using 1.5-T MRI (Achieva, Philips, The Netherlands) in 46 patients with different cardiac diseases. Global functional parameters, LV mass, imaging time and reporting time were evaluated and compared in each patient. RESULTS: Functional parameters and mass were significantly different in the two sequences [3D end-diastolic volume (EDV) = 129 ± 44 ml vs 2D EDV = 134 ± 49 ml; 3D end-systolic volume (ESV) = 77 ± 44 ml vs 2D ESV = 73 ± 50 ml; 3D ejection fraction (EF) = 43 ± 15% vs 2D EF = 48 ± 15%; p < 0.05], although an excellent correlation was found for LV EF (r = 0.99). Bland-Altman analysis showed small confidence intervals with no interactions on volumes (EF limits of agreement = 2.7; 7.6; mean bias 5%). Imaging time was significantly lower for 3D-cine sequence (18 ± 1 s vs 95 ± 23 s; p < 0.05), although reporting time was significantly longer for the 3D-cine sequence (29 ± 7 min vs 8 ± 3 min; p < 0.05). CONCLUSIONS: A 3D-cine sequence can be advocated as an alternative to 2D-cine sequence for LV EF assessment in patients for whom shorter imaging time is desirable.
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Maffei et al. (2010) conducted a cross-sectional in Cardiac diseases (n=46). Single-breath-hold 3D k-t BLAST cine b-SSFP vs. Multiple-breath-hold 2D cine b-SSFP was evaluated on Left ventricular ejection fraction (EF) (p=<0.01). Single-breath-hold 3D k-t BLAST cine MRI significantly underestimated left ventricular ejection fraction compared to 2D cine MRI (43% vs 48%, p<0.01), though the methods showed excellent correlation.
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