Key result
Pharmacological restoration of the transient outward potassium current (Ito,f) during heart failure increases calcium influx to improve contractility and restores the transmural gradient in early repolarization.
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May identify Ito,f restoration as an HF contractility target; leaves open clinical translation.
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Kirstine Calløe (2019) studied Heart failure and cardiac electrophysiology. Transient outward potassium channel activator (e.g., NS5806) was evaluated. Pharmacological restoration of the transient outward potassium current (Ito,f) during heart failure increases calcium influx to improve contractility and restores the transmural gradient in early repolarization.
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