Key result
Changes in modifiable coronary risk factors accounted for 66% (95% CI, 48-97; P<0.001) of the 3% annual decline in total coronary heart disease incidence.
Why the study?
Are contemporary trends in the incidence of coronary heart disease associated with changes in modifiable coronary risk factors in healthy adults?
Cohort (n=29,582)
No
Are contemporary trends in the incidence of coronary heart disease associated with changes in modifiable coronary risk factors in healthy adults?
Effect estimate: 66% (95% CI 48-97)
p-value: p=<0.001
Favorable changes in modifiable risk factors, particularly cholesterol, blood pressure, and smoking, account for the majority of the decline in acute coronary heart disease incidence.
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Supports risk factor control in primary prevention; extends prior data by quantifying contributions to recent CHD declines.
Mannsverk et al. (2015) conducted a cohort in Coronary heart disease (n=29,582). Changes in modifiable coronary risk factors was evaluated on Proportion of the decline in total coronary heart disease accounted for by changes in coronary risk factors (66%, 95% CI 48-97, p=<0.001). Changes in modifiable coronary risk factors accounted for 66% (95% CI, 48-97; P<0.001) of the 3% annual decline in total coronary heart disease incidence.
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