Key result
Neutralizing antibody mismatch linked to TBE vaccine failure in 2 adolescents with severe neurologic sequelae.
Why the study?
Does high neutralizing antibody mismatch cause vaccine failure in children with severe tick-borne encephalitis?
Population
Two adolescents (13 and 16 years old) with severe tick-borne encephalitis and vaccination breakthrough
Design
Case report
Authors
Loading...
May link strain mismatch to pediatric TBE vaccine failure; hypothesis-generating and should not yet change vaccination practice.
Case Report (n=2)
Does high neutralizing antibody mismatch cause vaccine failure in children with severe tick-borne encephalitis?
High neutralizing antibody mismatch between the infecting TBE virus strain and the vaccine strain may explain severe vaccine breakthrough and neurologic sequelae in children.
Geißlreiter et al. (2023) conducted a case report in Severe tick-borne encephalitis (TBE) with vaccination breakthrough (n=2). TBE vaccination was evaluated on Neutralizing antibody mismatch and vaccine failure. High neutralizing antibody mismatch between the infecting and vaccine strains was identified as a possible cause of TBE vaccination failure in 2 adolescents with severe neurologic sequelae.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: