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August 7, 2024npj VaccinesOpen Access

Tick-borne encephalitis vaccine breakthrough infections induce aberrant T cell and antibody responses to non-structural proteins

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Authors

AAAmare AregayJSJan SlunečkoMKMiša Korva

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Overview

Comparative study reveals impaired non-structural protein antibody responses in vaccinated encephalitis patients, suggesting altered breakthrough immunity.

Key Points

  • Tick-borne encephalitis virus breakthrough infections induce impaired antibody responses to non-structural protein 1 alongside robust non-structural T cell responses.
  • Moderate to severe disease occurred predominantly during hospitalization, while breakthrough cases showed significantly reduced levels of NS1-specific antibodies.
  • Comparative evaluation of breakthrough cases demonstrates that lower non-structural protein 1 antibody levels correlate with disease severity, highlighting altered protective immunity.

Cite This Study

Aregay et al. (2024) studied this question.

synapsesocial.com/papers/68e5d23bb6db64358756804ehttps://doi.org/10.1038/s41541-024-00936-7
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Poor virus-specific T-cell responses early after tick-borne encephalitis virus infection correlate with disease severity2024 · 8 citations
  2. 2High neutralizing antibody mismatch as a possible reason for vaccine failure in two children with severe tick-borne encephalitis2023 · 7 citations
  3. 3The importance of the role of T-cell immunity in the development of modern tick-borne encephalitis vaccines2024 · 1 citations
  4. 4Response of host immune system to tick borne encephalitis virus2025 · 1 citations
  5. 5A replication-defective tick-borne encephalitis virus generated by NS1 trans-complementation confers robust protective efficacy2026