Key result
Vaccination breakthrough tick-borne encephalitis was associated with more severe acute illness (P=0.001), longer hospitalization (P=0.002), and higher ICU need (P=0.009) than in unvaccinated patients.
Why the study?
Does previous TBE vaccination affect the severity of acute illness in patients who develop tick-borne encephalitis compared to unvaccinated patients?
Population
117 adult patients diagnosed with tick-borne encephalitis at a single medical center over a 16-year period…
Comparison
Previous vaccination against TBE vs Unvaccinated sex- and age-matched patients…
Design
Case-control
Authors
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Breakthrough TBE was associated with more severe acute illness; leaves open whether vaccination modifies disease course or selects higher-risk patients.
Cohort (n=117)
No
Does previous TBE vaccination affect the severity of acute illness in patients who develop tick-borne encephalitis compared to unvaccinated patients?
p-value: p=0.001
Patients who develop tick-borne encephalitis despite prior vaccination appear to experience a more severe acute illness than unvaccinated patients.
Lotrič‐Furlan et al. (2017) conducted a cohort in Tick-borne encephalitis (n=117). TBE vaccination vs. Unvaccinated patients was evaluated on Severity of acute illness (p=0.001). Vaccination breakthrough tick-borne encephalitis was associated with more severe acute illness (P=0.001), longer hospitalization (P=0.002), and higher ICU need (P=0.009) than in unvaccinated patients.
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