Why the study?
Double cryoenergy application was introduced into clinical practice due to single-application inferiority to RFA, but experience regarding efficacy and coronary artery damage was limited.
Does double cryoenergy application create effective lesion volumes and what is the risk of coronary artery damage in a growing myocardium model?
Population
Five piglets
Comparison
Two sequential cycles of cryoenergy at -75°C for 4 minutes at the atrioventricular groove
Design
Animal study
Follow-up
6 months
Key result
Double cryoenergy application in a piglet model caused minor coronary artery injury in 2 of 29 lesions and produced ventricular lesions deeper than atrial lesions (4.06 vs 3.58 mm, P<0.05).
Authors
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Minor coronary injury risk in piglet model warrants histologic caution in immature hearts; leaves open translation to pediatric ablation.
Does double cryoenergy application create effective lesion volumes and what is the risk of coronary artery damage in a growing myocardium model?
Double cryoenergy application in a growing myocardium piglet model creates effective lesions but can cause subclinical minor coronary artery wall injury detectable only by histology.
Schneider et al. (2019) studied Growing myocardium (piglet model) (n=5). Double cryoenergy application was evaluated on Lesion volume and risk of coronary artery damage. Double cryoenergy application in a piglet model caused minor coronary artery injury in 2 of 29 lesions and produced ventricular lesions deeper than atrial lesions (4.06 vs 3.58 mm, P<0.05).
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