Why the study?
Does a cryolesion in the left ventricle cause acute and chronic electrophysiological changes and arrhythmias in a canine model?
Does a cryolesion in the left ventricle cause acute and chronic electrophysiological changes and arrhythmias in a canine model?
Cryosurgery in the left ventricle produces transient acute ventricular arrhythmias originating from the lesion border, but does not typically cause chronic arrhythmias.
Answers are grounded in this paper and cite their sources.
Acute cryolesion arrhythmias largely resolve in dogs; leaves open translation to human cryosurgery safety.
The acute and chronic electrophysiological effects of a cryolesion produced in the left ventricle were studied in six dogs. All dogs had frequent ventricular premature beats (VPB) and five of six dogs had ventricular tachycardia during the first 4 days after the cryolesion; only one of the six dogs continued to have VPBs after 1 week, and this dog had identical VPBs before the creation of the cryolesion. Neither control dog had VPBs. Two additional dogs underwent epicardial and transmural mapping studies immediately after production of a cryolesion. VPBs in these animals were shown to originate at the border of the cryolesion. Epicardial activation sequence during normal sinus rhythm was not altered by the chronic cryolesion. The border zone of the chronic cryolesion was sharply demarcated with normal potentials recorded outside of the lesion and "extrinsic" potentials recorded within.
No takes yet. Share an insight, caveat, or question.
Klein et al. (1979) studied Myocardial cryolesion (n=10). Cryosurgery (cryolesion in the left ventricle) vs. Control (no cryolesion) was evaluated on Ventricular premature beats (VPB) during the first 4 days.
Synapse has enriched 10 related papers. Consider them for comparative context: