Neural mechanisms of genetic risk for impulsivity and violence in humans
Why the study?
Does the low expression variant of the MAOA gene alter brain structure and function in healthy human volunteers?
Population
Healthy human volunteers
Comparison
Low expression variant of the X-linked monoamine… vs High expression allele of the MAOA gene
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
MAOA low-expression variant links to limbic alterations in healthy adults; hypothesis-generating for aggression mechanisms, should not yet change practice.
Structured PICO
Does the low expression variant of the MAOA gene alter brain structure and function in healthy human volunteers?
P
Population
Healthy human volunteers
I
Intervention
Low expression variant of the X-linked monoamine oxidase A (MAOA) gene
C
Comparator
High expression allele of the MAOA gene
O
Outcome
Brain structure and function assessed with MRI (including limbic volume, amygdala responsiveness, and prefrontal reactivity)surrogate
The low expression MAOA variant is associated with structural and functional differences in limbic circuitry, providing a potential neural mechanism for its link to impulsive aggression.
Cite This Study
Meyer‐Lindenberg et al. (2006) studied this question.