Key result
Depression increased the risk of incident heart failure (HR 2.08; 95% CI 1.89-2.28), and heart failure increased the risk of incident depression (HR 1.34; 95% CI 1.17-1.54).
Why the study?
To determine whether a bi-directional relationship exists between depression and HF within a single primary care population using longitudinal electronic health records.
Does a bi-directional relationship exist between depression and heart failure such that each increases the risk of developing the other?
Population
10,649 people with depression and 5,911 with HF, each matched 1:1 with unaffected referents
Comparison
Depression or HF cohorts vs matched unaffected referents
Design
Retrospective cohort study
Follow-up
Approximately 4-6 years
Authors
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Supports bidirectional screening in HF and depression care; leaves open causality and intervention effects.
Cohort (n=33,120)
Does a bi-directional relationship exist between depression and heart failure such that each increases the risk of developing the other?
Effect estimate: HR 2.08 (HF) / HR 1.34 (Depression) (95% CI 1.89-2.28 (HF) / 1.17-1.54 (Depression))
There is a significant bi-directional association between depression and heart failure, independent of age, sex, and multimorbidity.
Bobo et al. (2020) conducted a cohort in Depression and Heart Failure (n=33,120). Depression or Heart Failure vs. Unaffected matched referents was evaluated on Newly diagnosed heart failure and newly diagnosed depression (HR 2.08 (HF) / HR 1.34 (Depression), 95% CI 1.89-2.28 (HF) / 1.17-1.54 (Depression)). Depression increased the risk of incident heart failure (HR 2.08; 95% CI 1.89-2.28), and heart failure increased the risk of incident depression (HR 1.34; 95% CI 1.17-1.54).
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