Why the study?
Does a diagnostic strategy combining low clinical probability and normal D-dimer concentration safely exclude pulmonary embolism in patients with suspected PE?
Does a diagnostic strategy combining low clinical probability and normal D-dimer concentration safely exclude pulmonary embolism in patients with suspected PE?
The combination of low clinical probability and normal D-dimer concentration safely excludes pulmonary embolism without the need for further diagnostic testing.
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Supports ruling out PE without imaging in low-probability patients with normal D-dimer; leaves open need for prospective validation before practice change.
Kruip et al. (2002) studied this question.
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