Identifying Individuals at Risk for Cardiovascular Events Across the Spectrum of Blood Pressure Levels
Key result
A 10-year ASCVD risk ≥7.5% identified 64% of untreated participants who experienced an event, while half of excess ASCVD events occurred in those with elevated SBP not recommended for therapy.
Why the study?
Does multivariable risk assessment identify individuals at risk for ASCVD events across the spectrum of systolic blood pressure levels?
Population
18,898 participants aged 45 to 64 years from the Framingham Offspring and Atherosclerosis Risk in…
Comparison
Multivariable risk assessment using Pooled… vs Untreated systolic blood pressure <120 mm Hg
Design
Cohort
Follow-up
10 years
Authors
Discussion
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Member takes
Implication
Risk stratification may identify most events in untreated adults across SBP levels; hypothesis-generating for expanded thresholds, pending randomized trials.
Study Design
Type
Cohort (n=18,898)
Multicenter
Yes
Structured PICO
Does multivariable risk assessment identify individuals at risk for ASCVD events across the spectrum of systolic blood pressure levels?
P
Population
18,898 participants aged 45 to 64 years (78% white; 22% black) from the Framingham Offspring and Atherosclerosis Risk in Communities studies
I
Intervention
Multivariable risk assessment using Pooled Cohort risk equations and stratification by systolic blood pressure levels
C
Comparator
Untreated systolic blood pressure <120 mm Hg (used as reference)
O
Outcome
Atherosclerotic cardiovascular disease (ASCVD) events at 10 yearshard clinical
Multivariable risk assessment using the Pooled Cohort equations can identify a significant proportion of individuals who will experience ASCVD events despite having blood pressure levels not currently recommended for treatment.
Cite This Study
Karmali et al. (2015) conducted a cohort in Atherosclerotic cardiovascular disease (n=18,898). Multivariable risk assessment (Pooled Cohort risk equations) vs. Untreated SBP <120 mm Hg was evaluated on Excess ASCVD events. A 10-year ASCVD risk ≥7.5% identified 64% of untreated participants who experienced an event, while half of excess ASCVD events occurred in those with elevated SBP not recommended for therapy.