Systolic Blood Pressure Levels Among Adults With Hypertension and Incident Cardiovascular Events
Key result
In adults with hypertension, standard systolic blood pressure (120-139 mm Hg) showed no difference in incident cardiovascular events compared to <120 mm Hg (HR 1.00; 95% CI 0.85-1.17).
Why the study?
Does a systolic blood pressure lower than 120 mm Hg reduce incident cardiovascular events compared to 120-139 mm Hg in adults with hypertension?
Population
4,480 adults with hypertension but without prevalent cardiovascular disease at baseline from the…
Comparison
Elevated systolic blood pressure or standard… vs Low systolic blood pressure (<120 mm Hg)
Design
Cohort
Follow-up
median 21.8 years
Authors
Discussion
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Implication
No CV benefit seen with SBP <120 vs 120-139 mm Hg in cohort data; leaves open optimal targets pending randomized trials.
Study Design
Type
Cohort (n=4,480)
Multicenter
Yes
Structured PICO
Does a systolic blood pressure lower than 120 mm Hg reduce incident cardiovascular events compared to 120-139 mm Hg in adults with hypertension?
P
Population
4,480 adults with hypertension and no prevalent cardiovascular disease at baseline, followed for a median of 21.8 years.
E
Exposure
Elevated systolic blood pressure (≥140 mm Hg) or standard systolic blood pressure (120-139 mm Hg)
C
Comparator
Low systolic blood pressure (<120 mm Hg)
O
Outcome
Incident composite cardiovascular events (heart failure, ischemic stroke, myocardial infarction, or death related to coronary heart disease)composite
Main Result
Hazard Ratio: 1 (95% CI 0.85–1.17)
In adults with hypertension, maintaining a systolic blood pressure below 120 mm Hg did not further reduce the risk of incident cardiovascular events compared to a target of 120-139 mm Hg.
Cite This Study
Rodríguez et al. (2014) conducted a cohort in hypertension (n=4,480). Standard systolic blood pressure (120-139 mm Hg) vs. Low systolic blood pressure (<120 mm Hg) was evaluated on Incident composite CV events (heart failure, ischemic stroke, myocardial infarction, or death related to coronary heart disease) (HR 1.00, 95% CI 0.85-1.17). In adults with hypertension, standard systolic blood pressure (120-139 mm Hg) showed no difference in incident cardiovascular events compared to <120 mm Hg (HR 1.00; 95% CI 0.85-1.17).