Key result
A review of the literature supports a link between diabetes and sudden cardiac death, emphasizing the predisposing roles of hyperglycemia, autonomic neuropathy, and anti-diabetic agents.
Why the study?
What are the underlying mechanisms of dysrhythmia and electrocardiographic changes in diabetic patients, and how do they impact the incidence of sudden cardiac death?
What are the underlying mechanisms of dysrhythmia and electrocardiographic changes in diabetic patients, and how do they impact the incidence of sudden cardiac death?
This review emphasizes the underestimated susceptibility to dysrhythmias in diabetic patients and highlights the link between diabetes and sudden cardiac death.
Highlights underestimated SCD risk in diabetes; leaves open mechanistic confirmation and preventive strategies in prospective trials.
BACKGROUND: The incidence of sudden cardiac death (SCD) is increasing in diabetes mellitus. Susceptibility to dysrhythmias and the reliability of an electrocardiogram in diabetic hearts are debatable issues. OBJECTIVES: To highlight the underlying mechanism of dysrhythmia and electrocardiographic changes in diabetic patients and the impact on the incidence of SCD. METHODS: Most the pertinent articles (English and non-English) published in Medline, Scopus and EBSCO Host research databases have been reviewed. RESULTS AND CONCLUSION: In the absence of systematic reviews, susceptibility to dysrhythmias and electrical instability in diabetic patients are underestimated. This susceptibility has been found to be enhanced, unchanged or reduced in different studies. To find a link between SCD and diabetes, the published studies provide controversial results; however, the majority of studies with a long-term follow-up support this link. The role of hyperglycemia, autonomic neuropathy and anti-diabetic agents as predisposing factors deserve more attention to fortify the clinical judgment and decrease the incidence of SCD.
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Ayman El‐Menyar (2006) conducted a review in Diabetes mellitus. A review of the literature supports a link between diabetes and sudden cardiac death, emphasizing the predisposing roles of hyperglycemia, autonomic neuropathy, and anti-diabetic agents.
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