Key result
Review outlines arrhythmia mechanisms in diabetes and identifies therapeutic goals to reduce sudden cardiac death.
Why the study?
The pathogenetic mechanisms and clinical course of cardiac arrhythmias in diabetes mellitus require more detailed research to guide effective prevention and treatment.
This review emphasizes the complex pathophysiological mechanisms linking diabetes mellitus to cardiac arrhythmias and highlights the need for an integrated diagnostic and therapeutic approach to prevent sudden cardiac death.
Should not yet change practice in diabetic arrhythmia care; leaves open mechanistic targets for prospective validation.
Despite a comprehensive study of such comorbidities as cardiovascular diseases and diabetes mellitus (DM), the pathogenetic mechanisms and clinical course of cardiac arrhythmias in this pathology require more detailed research. Cardiac arrhythmias are the leading cause of sudden cardiac death in patients with diabetes, presenting a serious clinical problem. The pathogenesis of arrhythmias in DM is complex and multifaceted. Numerous risk factors, including chronic hyperglycemia, create a background for structural remodeling of the myocardium, which is an early marker of heart muscle dysfunction. Concurrently, dysregulation of the autonomic nervous system leads to significant changes in the electrical activity of the heart and causes rhythm disorders. The variety of arrhythmias, including supraventricular and ventricular arrhythmias as well as bradyarrhythmias, creates significant diagnostic and therapeutic challenges for medical professionals and necessitates an integrated approach to diagnosing this category of patients. Understanding the mechanisms of arrhythmia development in DM is crucial for their effective prevention and treatment. This review examines the pathophysiological mechanisms underlying arrhythmias in DM and identifies the main therapeutic goals for reducing the risk of sudden cardiac death.
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Zatsepina et al. (2025) conducted a review in Cardiac arrhythmias and diabetes mellitus. This review highlights the complex pathophysiological mechanisms underlying arrhythmias in diabetes mellitus and identifies therapeutic goals to reduce the risk of sudden cardiac death.
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