Type 2 Diabetes: RENAAL and IDNT—The Emergence of New Treatment Options
Why the study?
Does an angiotensin receptor blocker (ARB) interfere with the natural history of diabetic nephropathy in a blood pressure-independent fashion?
Population
Patients with type 2 diabetes and nephropathy (advanced stages or microalbuminuria)
Design
Review
Authors
Discussion
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Member takes
Implication
May support ARB consideration in diabetic nephropathy; leaves open blood pressure-independent effects.
Structured PICO
Does an angiotensin receptor blocker (ARB) interfere with the natural history of diabetic nephropathy in a blood pressure-independent fashion?
P
Population
Patients with type 2 diabetes and nephropathy (advanced stages or microalbuminuria)
I
Intervention
Angiotensin receptor blockers (ARBs)
O
Outcome
Deterioration in renal function
Evidence from major trials supports ARBs as the foundational therapy for forestalling renal deterioration in patients with type 2 diabetes and nephropathy.
Limitations
- Head-to-head studies comparing ACE inhibitors to ARBs in diabetic nephropathy are not likely to occur
Cite This Study
Sica et al. (2002) studied this question.