Twenty-Five–Year Trends in In-Hospital and Long-Term Outcome After Percutaneous Coronary Intervention
Key result
Percutaneous coronary intervention in recent years (2003-2004) significantly reduced in-hospital mortality compared to 1979-1989 (1.8% vs 3.0%, P<0.001), despite higher-risk patient profiles.
Why the study?
Do technological and pharmacological advances in percutaneous coronary intervention improve in-hospital and long-term outcomes over a 25-year period?
Population
18,575 unique patients who underwent 24,410 percutaneous coronary interventions at Mayo Clinic over 25 years
Comparison
Percutaneous coronary intervention in recent… vs Percutaneous coronary intervention in earlier…
Design
Cohort
Authors
Discussion
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Implication
Improved PCI survival in higher-risk patients supports ongoing innovation; extends observational trends but leaves causal drivers open.
Study Design
Type
Cohort (n=18,575)
Multicenter
No
Structured PICO
Do technological and pharmacological advances in percutaneous coronary intervention improve in-hospital and long-term outcomes over a 25-year period?
P
Population
18,575 unique patients who underwent 24,410 percutaneous coronary interventions at Mayo Clinic over 25 years (1979-2004)
I
Intervention
Percutaneous coronary intervention in recent time periods (1996-2003 [n=10,952] and 2003-2004 [n=2,730])
C
Comparator
Percutaneous coronary intervention in earlier time periods (1979-1989 [n=3,708] and 1990-1996 [n=7,020])
O
Outcome
In-hospital mortality, procedural success, need for emergency bypass surgery, and long-term follow-up mortality, death or MI, and death, MI, or revascularizationhard clinical
Main Result
Absolute Event Rate: 1.8% vs 3%
p-value: p=<0.001
Procedural success and long-term outcomes after PCI have significantly improved over 25 years despite patients having higher-risk profiles.
Cite This Study
Singh et al. (2007) conducted a cohort in Coronary artery disease requiring percutaneous coronary intervention (n=18,575). Percutaneous coronary intervention (2003-2004 era) vs. Percutaneous coronary intervention (1979-1989 era) was evaluated on In-hospital mortality (p=<0.001). Percutaneous coronary intervention in recent years (2003-2004) significantly reduced in-hospital mortality compared to 1979-1989 (1.8% vs 3.0%, P<0.001), despite higher-risk patient profiles.