Key result
Carotid artery stenting in patients aged 75 or older resulted in a 30-day morbi-mortality rate of 8.3% compared to 2.3% in younger patients, with no statistically significant difference.
Why the study?
Does carotid artery stenting increase the 30-day risk of stroke and death in patients aged ≥75 years compared to younger patients with severe carotid stenosis?
Cohort (n=174)
No
Does carotid artery stenting increase the 30-day risk of stroke and death in patients aged ≥75 years compared to younger patients with severe carotid stenosis?
Absolute Event Rate: 8.3% vs 2.3%
p-value: p=n.s.
Carotid artery stenting in patients aged 75 or older shows a trend toward higher peri-procedural complications compared to younger patients, highlighting the need for careful patient selection and further randomized trials.
May warrant caution in elderly carotid stenting patients; leaves open need for randomized safety confirmation.
Carotid artery stenting (CAS) is often considered the preferred treatment for severe carotid occlusive disease in patients labelled as “high risk,” including those aged 75 or more. We analyzed 30-day stroke risk and death rates after carotid artery stenting (CAS) for severe symptomatic or asymptomatic carotid stenosis in 55 patients (60 lesions) aged 75 or more and compared the results with those of 119 patients (130 lesions) less than 75 years old. All procedures were performed with protection devices (balloon protection) and were technically successful. Peri-procedural mortality and morbidity of CAS for elderly patients were 1.7% and 6.7%, respectively, but those for younger patients were 0% and 2.3%, respectively. The elderly patients tended to have a high complication rate, although it was not statistically significant. Therefore there was no significant difference in clinical baseline characteristics between the 2 groups. Randomized data that establish the efficacy of CEA versus medical management are not available for elderly patients, especially for individuals aged 80 years or older. Octogenarians should be considered high-risk patients for CAS. Randomized trial data are needed to compare the CAS versus CEA peri-procedural risk of stroke and death by age. Pending results from randomized studies, care should be exercised in selecting octogenarians for CAS.
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Nonaka et al. (2008) conducted a cohort in Severe symptomatic or asymptomatic carotid stenosis (n=174). Carotid artery stenting (CAS) vs. CAS in patients <75 years old was evaluated on 30-day morbi-mortality (p=n.s.). Carotid artery stenting in patients aged 75 or older resulted in a 30-day morbi-mortality rate of 8.3% compared to 2.3% in younger patients, with no statistically significant difference.
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