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December 1, 1986Journal of Intensive Care Medicine

Analytic Review: Thrombolytic Therapy in Acute Myocardial Infarction

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Why the study?

Does thrombolytic therapy improve coronary recanalization and reduce morbidity and mortality in patients with acute myocardial infarction?

Population

Patients with acute myocardial infarction

Design

Review

Authors

PZPeter L. ZwernerMedical University of South CarolinaJGJoel M. GoreGeneral Cardiology

Discussion

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Implication

Highlights thrombolysis benefits in AMI; leaves open need for updated RCTs versus modern reperfusion.

Structured PICO

Does thrombolytic therapy improve coronary recanalization and reduce morbidity and mortality in patients with acute myocardial infarction?

P
Population
Patients with acute myocardial infarction
I
Intervention
Thrombolytic therapy (intravenous and intracoronary administration, including tissue plasminogen activator)
O
Outcome
Coronary artery recanalization/reperfusion, morbidity, and mortality

Thrombolytic therapy, particularly intravenous tissue plasminogen activator, is an effective treatment for acute myocardial infarction that promotes coronary recanalization and reduces morbidity and mortality.

Cite This Study

Zwerner et al. (1986) studied this question.

synapsesocial.com/papers/6a110ba06da82ae745f33ee0https://doi.org/10.1177/088506668600100602
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1FIBRINOLYTIC TREATMENT IN ACUTE MYOCARDIAL INFARCTION1971 · 71 citations
  2. 2Timolol-Induced Reduction in Mortality and Reinfarction in Patients Surviving Acute Myocardial Infarction1981 · 1,677 citations
  3. 3The Thrombolysis in Myocardial Infarction (TIMI) Trial1985 · 3,192 citations
  4. 4Intravenous recombinant tissue-type plasminogen activator in patients with acute myocardial infarction: a report from the NHLBI thrombolysis in myocardial infarction trial.1986 · 291 citations
  5. 5A randomized trial of intravenous and intracoronary streptokinase in patients with acute myocardial infarction.1984 · 140 citations