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November 11, 2008Cardiology

Early thrombolytic reperfusion appears beneficial in acute transmural myocardial infarction, although markers of success or failure do not necessarily correlate with short-term mortality.

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Why the study?

Does intracoronary thrombolytic reperfusion reduce mortality and improve clinical markers in patients with early acute transmural myocardial infarction?

Population

Patients with early acute transmural myocardial infarction

Comparison

Intracoronary thrombolytic reperfusion vs Nonreperfused patients

Design

Review

Key result

Early thrombolytic reperfusion appears beneficial in acute transmural myocardial infarction, although markers of success or failure do not necessarily correlate with short-term mortality.

Authors

MDMarcus A. DeWoodEAEzra A. Amsterdam

Discussion

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Member takes

Overview

Early thrombolysis may benefit transmural MI; leaves open whether reperfusion markers predict mortality.

Structured PICO

Does intracoronary thrombolytic reperfusion reduce mortality and improve clinical markers in patients with early acute transmural myocardial infarction?

P
Population
Patients with early acute transmural myocardial infarction
I
Intervention
Intracoronary thrombolytic reperfusion
C
Comparator
Nonreperfused patients
O
Outcome
Mortality

This review suggests that early intracoronary thrombolytic reperfusion is beneficial for acute transmural myocardial infarction, though surrogate markers may not predict short-term mortality.

Limitations

  • Markers of success or failure do not necessarily correlate with short-term mortality

Cite This Study

DeWood et al. (2008) conducted a review in Acute transmural myocardial infarction. Thrombolytic therapy vs. Nonreperfused patients was evaluated on Mortality and markers of success or failure. Early thrombolytic reperfusion appears beneficial in acute transmural myocardial infarction, although markers of success or failure do not necessarily correlate with short-term mortality.

synapsesocial.com/papers/6a15c1c7a2352da34782df29https://doi.org/10.1159/000173884
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Thrombolysis in the Treatment of Acute Transmural Myocardial Infarction1987 · 30 citations
  2. 2Analytic Review: Thrombolytic Therapy in Acute Myocardial Infarction1986 · 3 citations
  3. 3Aggressive Interventional Treatment of Acute Myocardial Infarction2008 · 9 citations
  4. 4The Restoration of Coronary Blood Flow in Acute Myocardial Infarction1998 · 3 citations
  5. 5Reperfusion therapy in acute myocardial infarction: Present status and controversy1990 · 6 citations