Key result
No prior heart disease is linked to ~90% lower risk of recurrent ischemic stroke.
Why the study?
Cerebrovascular events are a leading cause of disability and death, motivating the investigation of potential underlying causes of recurrent ischemic stroke.
Cohort (n=100)
No
Effect estimate: RR 0.10 (95% CI 0.03-0.33)
A history of heart disease is a significant predictor of recurrent ischemic stroke, emphasizing the importance of cardiovascular risk management in stroke survivors.
May support risk stratification by heart disease history in stroke survivors; leaves open whether targeted interventions reduce recurrence.
Introduction: Cerebrovascular events are one of the most common causes of disability and the third leading cause of death in developed countries. Herein, we aimed to investigate the potential underlying causes of recurrent ischemic stroke. Methods: This study was a retrospective cohort study conducted in Razi Hospital, Tabriz, Iran between March 2018 and September 2020. Patients with the diagnosis of recurrent ischemic stroke during the study period were eligible to be included. Baseline characteristics and data on the recurrence were collected using chart reviews. Also, binary logistic regression was used to examine the factors related to recurrence. Results: Among one hundred participants with a mean age of 68.88 years, 59% were male. Hypertension, diabetes, heart disease, smoking, and hyperlipidemia were identified in 79%, 42%, 24%, 15%, and 15%, respectively. The average recurrence time of stroke was about 2.52 years. According to our findings, a significant relationship between the history of heart diseases and ischemic stroke recurrence was observed (risk ratio: 0.10: 95% confidence interval: 0.03-0.33). Conclusion: We found no significant association between ischemic stroke recurrence and underlying diseases except for heart diseases. Further large-scale observational studies and meta-analyses are recommended to evaluate the possible association.
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Shaafi et al. (2024) conducted a cohort in Recurrent ischemic stroke (n=100). Absence of heart disease history vs. History of heart diseases was evaluated on Recurrent ischemic stroke (RR 0.10, 95% CI 0.03-0.33). The absence of a history of heart diseases was associated with a 90% lower risk of recurrent ischemic stroke (RR 0.10).
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