Key result
No history of heart disease is linked to ~90% lower risk of recurrent ischemic stroke.
Why the study?
Cerebrovascular events are a leading cause of disability and death, motivating an investigation into the potential underlying causes of recurrent ischemic stroke.
Cohort (n=100)
No
Effect estimate: RR 0.10 (95% CI 0.03-0.33)
In a retrospective cohort, a history of heart disease was significantly associated with ischemic stroke recurrence.
History of heart disease may identify higher-risk patients for recurrent ischemic stroke; leaves open whether targeted prevention alters outcomes.
Background: Cerebrovascular events are one of the most common causes of disability and the third leading cause of death in developed countries. Herein, we aimed to investigate the potential underlying causes of recurrent ischemic stroke. Methods: This study was a retrospective cohort study which conducted in Razi Hospital, Tabriz, Iran between March 2018 and September 2020. Patients with the diagnosis of recurrent ischemic stroke during the study period were eligible to be included. Baseline characteristics and data on the recurrence were collected using chart reviews. Binary logistic regression was used to examine the factors related with recurrence. Results: One hundred participants with a mean age of 68.88 years were included in the study among them 59% were male. Hypertension, diabetes, heart disease, smoking and hyperlipidemia identified in 79%, 42%, 24%, 15%, and 15%, respectively. The average recurrence time of stroke was about 2.52 years. There was only a significant relationship between history of heart diseases and ischemic stroke recurrence (risk ratio: 0.10: 95% confidence interval: 0.03-0.33). Conclusions: We found no significant association between ischemic stroke recurrence and underlying diseases except for heart diseases. Further large-scale observational studies and meta-analysis are recommended to evaluate the association.
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Shaafi et al. (2023) conducted a cohort in Recurrent ischemic stroke (n=100). Without history of heart diseases vs. History of heart diseases was evaluated on Recurrent ischemic stroke (RR 0.10, 95% CI 0.03-0.33). Patients without a history of heart diseases had a 90% lower risk of recurrent ischemic stroke compared to those with a history of heart diseases (RR 0.10).
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