Key result
SEC-FPLC coupled with mass spectrometry successfully quantified ceramides in bovine lipoprotein fractions, revealing that LDL is enriched with ceramides, predominantly C16:0-ceramide.
Population
4 nonpregnant and nonlactating Holstein dairy cows
Design
Preclinical
Authors
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No immediate clinical implications; leaves open ceramide roles in lipoproteins while extending analytical methods in animal models.
SEC-FPLC coupled with mass spectrometry is an effective method to quantify ceramides in bovine lipoprotein fractions, showing enrichment in LDL.
Phipps et al. (2017) studied Characterization of ceramide in bovine lipoproteins (n=4). Size exclusion chromatography by fast protein liquid chromatography (SEC-FPLC) coupled with mass spectrometry was evaluated on Ceramide profile of lipoprotein fractions. SEC-FPLC coupled with mass spectrometry successfully quantified ceramides in bovine lipoprotein fractions, revealing that LDL is enriched with ceramides, predominantly C16:0-ceramide.
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