Combination of Fimasartan and Statins in Patients With Hypertension and Dyslipidemia

Objective:We aimed to investigate the efficacy and safety of a combination of fimasartan 30 mg and moderate-intensity statins in patients with hypertension and dyslipidemia in a real-world setting.Methods: This non-interventional, multicenter, prospective observational study included 5,264 patients receiving a combination of fimasartan 30 mg and moderate-intensity statins with 12-week follow-up data.Co-primary efficacy outcomes were the percentage of patients that achieved target blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) control.Safety outcomes included adverse drug reactions and treatment-emergent adverse events.Results: At 12 weeks, the proportion of patients individually achieving target BP and LDL-C was 74.4% (95% confidence interval [CI], 73.2-75.5)and 85.6% (95% CI, 84.5-86.8),respectively.The proportion of patients achieving simultaneous control of target BP and LDL-C was 65.6% (95% CI, 64.1-67.2).The median (interquartile range; IQR) differences in systolic and diastolic BPs from baseline to 12 weeks were -8.0 mmHg (-19.0 to 0.0) and -4.0 mmHg (-11.0 to 0.0), respectively (both p-values <0.0001).The median (IQR) percentage change in LDL-C from baseline to 12 weeks was -11.5% (-33.5 to 4.8) (p<0.0001).No significant adverse drug reactions or serious treatment-emergent adverse events were reported during the study period.Conclusion: Findings of this study demonstrate that a combination of fimasartan 30 mg and moderate-intensity statins results in excellent control of BP and LDL-C levels without any safety issues.