Key result
Longer sleep onset latency links to greater 24-hour systolic BP variability in hypertension and T2D.
Why the study?
Hypertension is a primary complication in type 2 diabetes linked to increased morbidity and mortality, and circadian blood pressure variation captured by ambulatory blood pressure monitoring is closely influenced by sleep.
Are objective sleep parameters associated with diurnal blood pressure variability in patients with concurrent hypertension and type 2 diabetes?
Cross-Sectional (n=20)
Are objective sleep parameters associated with diurnal blood pressure variability in patients with concurrent hypertension and type 2 diabetes?
Effect estimate: β-coefficient 0.323 (95% CI 0.014, 0.632)
p-value: p=0.04
In patients with concurrent hypertension and type 2 diabetes, objective sleep parameters such as sleep onset latency and sleep efficiency are significantly associated with diurnal blood pressure variability.
Should not yet change practice; hypothesis-generating for sleep interventions on BP variability in hypertension with T2D.
Background Hypertension is a primary cardiovascular complication in type 2 diabetes associated with increased morbidity and mortality. Ambulatory blood pressure monitoring (ABPM) is essential for capturing circadian BP variation, which is closely influenced by sleep. Methods Twenty patients (63.75 ± 4.44 years old, 40% female, duration of T2D: 12.3 ± 6.24 years) underwent ABPM and actigraphy in a free‐living condition. Multi‐day sleep parameters including total sleep time, sleep efficiency, wake after sleep onset, sleep onset latency and number of awakenings were assessed by wrist actigraphy supplemented with sleep diary, ABPM was measured for 24 h during the sleep assessment period. Associations between parameters and ABPM across total sleep measurement period and the exact date of ABPM measurement were investigated, respectively. Linear regression was conducted for the relationship between objective sleep parameters and ABPM‐derived variables, adjusting for Age, sex, body mass index, duration of diabetes, antidiabetic medication uses and total physical activity MET (min/week). Results Sleep onset latency was associated with 24‐h coefficient of variance of systolic BP (β‐coefficient: 0.323, 95% CI: [0.014, 0.632], p = 0.04). Inter‐day sleep efficiency was inversely associated with SD and CV (SD: β‐coefficient:−0.373, 95% CI: [−0.676, −0.071], p = 0.02; CV: β‐coefficient:−0.588, 95% CI: [−1.141, −0.036], p = 0.04) of diastolic BP.
No takes yet. Share an insight, caveat, or question.
Zhao et al. (2026) conducted a cross-sectional in Concurrent hypertension and type 2 diabetes (n=20). Objective sleep parameters (actigraphy) was evaluated on Association between sleep onset latency and 24-h coefficient of variance of systolic BP (β-coefficient 0.323, 95% CI 0.014, 0.632, p=0.04). Sleep onset latency was positively associated with 24-hour coefficient of variance of systolic blood pressure (β-coefficient 0.323; 95% CI 0.014-0.632; p=0.04) in patients with hypertension and T2D.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: