An Integrated Heart Sound–Electrocardiogram Synchronization System for Early Detecting Left Ventricular Systolic Dysfunction in Pediatric Populations
Key result
Synchronized heart sound-ECG system detects pediatric LVSD with up to ~0.90 AUC.
- AUC 0.821 (3-6 years) and 0.896 (7-16 years)
- P<0.001
- n=212
Why the study?
Early detection of pediatric left ventricular systolic dysfunction remains challenging in resource-limited settings.
Does a synchronized heart sound-electrocardiogram (HS-ECG) system accurately detect left ventricular systolic dysfunction in children aged 3-16 years?
Population
212 children aged 3-16 years
Comparison
LVEF <= 55% (n = 80) vs LVEF > 55% (n = 132)
Design
Prospective cohort study
Authors
Discussion
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Implication
May aid non-invasive pediatric LVSD screening; hypothesis-generating and requires prospective validation before practice change.
Key Points
- The study aims to assess a novel synchronized heart sound-electrocardiogram (HS-ECG) system for early detection of left ventricular systolic dysfunction in pediatric populations.
- Prospective cohort study involving 212 children aged 3-16 years with LVSD classification based on LVEF.
- Children underwent synchronized HS-ECG recording using a high-fidelity wearable device.
- Wavelet analysis processed signals to derive cardiac acoustic biomarkers.
- In children aged 3-6 years, EMATc correlated inversely with LVEF (r = -0.529, p < 0.001) with AUC = 0.821; sensitivity 82.5%, specificity 84.7%.
- In those aged 7-16 years, EMAT showed superior performance (r = -0.609, p < 0.001; AUC = 0.896); sensitivity 82.5%, specificity 93.2%.
Study Design
Type
Cohort (n=212)
Structured PICO
Does a synchronized heart sound-electrocardiogram (HS-ECG) system accurately detect left ventricular systolic dysfunction in children aged 3-16 years?
P
Population
212 children aged 3-16 years, classified into case (LVEF ≤ 55%, n = 80) and control (LVEF > 55%, n = 132) groups with age stratification (3-6 and 7-16 years).
I
Intervention
Synchronized heart sound-electrocardiogram (HS-ECG) recording using a high-fidelity wearable device to derive cardiac acoustic biomarkers (CABs).
C
Comparator
Echocardiographic LVEF (reference standard).
O
Outcome
Diagnostic accuracy (correlation, AUC, sensitivity, specificity) of cardiac acoustic biomarkers for detecting left ventricular systolic dysfunction.surrogate
Main Result
Effect estimate: AUC 0.821 (3-6 years) and 0.896 (7-16 years)
p-value: p=<0.001
A novel synchronized HS-ECG wearable device provides accurate, age-specific cardiac acoustic biomarkers for the early detection of left ventricular systolic dysfunction in pediatric populations.
Cite This Study
Gao et al. (2026) conducted a cohort in Pediatric left ventricular systolic dysfunction (LVSD) (n=212). Synchronized heart sound-electrocardiogram (HS-ECG) system vs. Echocardiographic LVEF was evaluated on Detection of LVSD (LVEF ≤ 55%) (AUC 0.821 (3-6 years) and 0.896 (7-16 years), p=<0.001). A synchronized heart sound-electrocardiogram system accurately detected pediatric LVSD, yielding an AUC of 0.821 for EMATc in children aged 3-6 years and 0.896 for EMAT in those aged 7-16 years.