Key result
The genotype containing allele 7 in the DRD4 gene and genotype 9/9 in the DAT gene were significantly associated with a high level of vital exhaustion in men aged 25-64 years.
Why the study?
Are DRD4 and DAT gene polymorphisms associated with vital exhaustion in men aged 25-64 years?
Cross-Sectional (n=657)
No
Are DRD4 and DAT gene polymorphisms associated with vital exhaustion in men aged 25-64 years?
Specific dopamine receptor gene polymorphisms (DRD4 allele 7 and DAT genotype 9/9) are associated with higher levels of vital exhaustion in middle-aged men.
Should not yet change clinical evaluation of vital exhaustion; leaves open causal validation in prospective cohorts.
Objective: to study the association of the DRD4, DAT genes with vital exhaustion in an open 25—64-old-year male population. A random representative sample of 657 men aged 25—64 years, living in one of the Novosibirsk districts was examined within the WHO MONICA project in 1994. The MONICA-MOPSY test was used to estimate the level of vital exhaustion. The examined DRD4, DAT gene Polymorphisms were genotypes in the Laboratory of Molecular Genetic Studies, Therapy Research Institute, Siberian Branch, Russian Academy of Medical Sciences (Novosibirsk). Results. The genotype containing allele 7 in the dopamine receptor subtype 4 (DRD4) gene, as well as genotype 9/9 in the dopamine-transporter protein (DAT) gene are significantly associated with the high level of vital exhaustion. Conclusion. The vital exhaustion is significantly associated with certain DRD4, DAT gene polymorphisms in the open 25—64-year-old male population of Novosibirsk.
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Gafarov et al. (2012) conducted a cross-sectional in Vital exhaustion (n=657). DRD4 and DAT gene polymorphisms was evaluated on Level of vital exhaustion. The genotype containing allele 7 in the DRD4 gene and genotype 9/9 in the DAT gene were significantly associated with a high level of vital exhaustion in men aged 25-64 years.
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