Why the study?
This study aimed to assess the prognostic value of CMR-based tissue characterization in predicting response to CRT in patients with non-ischaemic cardiomyopathy.
Do CMR-based tissue parameters predict response to cardiac resynchronization therapy in patients with non-ischaemic cardiomyopathy?
Population
101 NICM patients before CRT implantation
Comparison
CRT responders vs CRT non-responders
Design
Retrospective analysis
Key result
CMR-based tissue parameters, specifically LGE burden ≤20% (OR 22.61; 95% CI 4.73-176.68; P<0.001), ECV ≤34%, and T2 ≤45 ms, independently predicted good response to cardiac resynchronization therapy.
Authors
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May aid CRT selection via CMR in non-ischaemic cardiomyopathy; leaves open prospective validation.
Cohort (n=101)
Do CMR-based tissue parameters predict response to cardiac resynchronization therapy in patients with non-ischaemic cardiomyopathy?
Effect estimate: OR 22.61 (95% CI 4.73-176.68)
p-value: p=<0.001
CMR-based tissue parameters, including LGE burden, ECV, and T2, effectively predict CRT response and clinical outcomes in patients with non-ischaemic cardiomyopathy.
Kim et al. (2025) conducted a cohort in Non-ischaemic cardiomyopathy (NICM) (n=101). Cardiac magnetic resonance (CMR) imaging was evaluated on Response to cardiac resynchronization therapy (CRT) (OR 22.61, 95% CI 4.73-176.68, p=<0.001). CMR-based tissue parameters, specifically LGE burden ≤20% (OR 22.61; 95% CI 4.73-176.68; P<0.001), ECV ≤34%, and T2 ≤45 ms, independently predicted good response to cardiac resynchronization therapy.