Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 27, 2010EP Europace

Multi-sequential CMR-predicted responders to cardiac resynchronization therapy had a significantly higher clinical response rate at 6 months than predicted non-responders (73% vs 17%, P<0.01).

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does multi-sequential CMR predict clinical response and long-term prognosis following cardiac resynchronization therapy in patients with advanced heart failure?

Population

40 subjects with cardiomyopathy and advanced heart failure on optimized medical therapy, recommended for…

Comparison

Multi-sequential cardiac magnetic resonance… vs CMR-predicted non-responders

Design

Cohort

Follow-up

6 months and 497 +/- 55 days

Key result

Multi-sequential CMR-predicted responders to cardiac resynchronization therapy had a significantly higher clinical response rate at 6 months than predicted non-responders (73% vs 17%, P<0.01).

Authors

ATAndrew J. TaylorMEMaros ElsikABA. Broughton

Discussion

Loading...

Member takes

Overview

May support CMR-guided CRT selection in advanced HF; leaves open prospective validation for outcome improvement.

Study Design

Type

Cohort (n=40)

Structured PICO

Does multi-sequential CMR predict clinical response and long-term prognosis following cardiac resynchronization therapy in patients with advanced heart failure?

P
Population
40 subjects with cardiomyopathy and advanced heart failure recommended for CRT, followed for a mean of 497 days post-CRT.
E
Exposure
Multi-sequential cardiac magnetic resonance imaging (CMR) to identify likely CRT responders (defined as > or =65 ms delay between septal and posterolateral wall contraction and no transmural scarring of the anteroseptal or posterolateral wall)
C
Comparator
CMR-predicted non-responders
O
Outcome
Clinical composite score at 6 months post-CRT and transplant-free survival at 497 +/- 55 days post-CRTcomposite

Main Result

Absolute Event Rate: 73% vs 17%

p-value: p=< 0.01

Multi-sequential CMR combining dyssynchrony and scar imaging effectively predicts clinical response and long-term transplant-free survival in patients undergoing CRT.

Cite This Study

Taylor et al. (2010) conducted a cohort in Cardiomyopathy and advanced heart failure (n=40). CMR-predicted responder status vs. CMR-predicted non-responder status was evaluated on Clinical response at 6 months post-CRT (p=< 0.01). Multi-sequential CMR-predicted responders to cardiac resynchronization therapy had a significantly higher clinical response rate at 6 months than predicted non-responders (73% vs 17%, P<0.01).

synapsesocial.com/papers/6a9f6233fba8082b88c07567https://doi.org/10.1093/europace/euq047
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac Magnetic Resonance Identifies Responders to Cardiac Resynchronization Therapy with an Assessment of Septal Scar and Left Ventricular Dyssynchrony2023 · 7 citations
  2. 2Impact of myocardial scar distribution and electrical remodeling on response to cardiac resynchronization therapy2026
  3. 3Refining cardiac resynchronization therapy: a comprehensive review on the role of advanced multimodality imaging2024 · 1 citations
  4. 4Prediction of Response to Cardiac Resynchronization Therapy: The Selection of Candidates for CRT (SCART) Study2006 · 153 citations
  5. 5Tissue characterization using cardiac magnetic resonance imaging and response to cardiac resynchronization therapy2025 · 3 citations