Key result
Impaired fasting glucose significantly increased aortic stiffness index (6.9 vs 5.01) and reduced aortic strain and distensibility compared to healthy controls.
Why the study?
Does impaired fasting glucose reduce aortic elasticity in patients without known atherosclerotic risk factors?
Case-Control (n=100)
No
Does impaired fasting glucose reduce aortic elasticity in patients without known atherosclerotic risk factors?
Absolute Event Rate: 6.9% vs 5.01%
p-value: p=<0.0001
Impaired fasting glucose is associated with reduced aortic elasticity and increased aortic stiffness, suggesting early atherosclerotic changes occur prior to overt diabetes.
Impaired fasting glucose may mark early aortic changes; hypothesis-generating and should not yet alter prediabetes management.
The pathophysiology of atherosclerosis development in patients with diabetes mellitus (DM) is similar to that in nondiabetics. However, atherosclerosis develops earlier and runs a rapid course in patients with diabetes. Aortic stiffness, strain and distensibility are the parameters used to assess an increase in arterial stiffness and can be measured by invasive and non-invasive methods.Aortic elastic properties were compared among patients with normal oral glucose tolerance test but impaired fasting glucose and healthy individuals. The study group consisted of 50 subjects with impaired fasting glucose who had no known risk factors for atherosclerosis. The control group was composed of the same number of volunteers.It was found that aortic strain and distensibility were reduced (8.78±4.3 vs. 10.65±2.6 p<0.01 and 4.1±2.1 vs. 5.1±1.7 p<0.01 respectively) and aortic stiffness index was significantly increased (6.9±3.2 vs. 5.01±1.6, p<0.0001) in patients with impaired fasting glucose compared to those in the control group.It was demonstrated that aortic elasticity was impaired in those with impaired fasting glucose, which indicates that these patients should be kept under close follow-up for cardiovascular events.
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Doğan et al. (2012) conducted a case-control in Impaired fasting glucose (n=100). Impaired fasting glucose vs. Normal fasting blood glucose (<100 mg/dl) was evaluated on Aortic stiffness index (p=<0.0001). Impaired fasting glucose significantly increased aortic stiffness index (6.9 vs 5.01) and reduced aortic strain and distensibility compared to healthy controls.
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