Key result
ACE gene D allele is not significantly linked to hypertension.
Why the study?
Arterial hypertension is caused by environmental factors and genetic predisposition, leading researchers to assess the association between ACE gene variants, environmental, biochemical, and anthropometric factors, and hypertension.
Population
73 patients aged 24 to 68 with BMI above 25 kg/m2
Comparison
ACE gene variants (insertion/deletion polymorphism)
Design
Observational study
Authors
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Does not support ACE genotyping in hypertension evaluation; leaves open gene-environment interactions in overweight adults.
Observational (n=73)
Absolute Event Rate: 53% vs 48%
The study suggests a potential association between the ACE gene D allele, certain environmental factors (smoking, alcohol, diet), and hypertension in overweight individuals, though differences in allele frequency were not statistically significant.
Pachocka et al. (2020) conducted an observational in Hypertension (n=73). ACE gene I/D polymorphism was evaluated on Frequency of the D allele in hypertensive vs normotensive groups. The ACE gene D allele frequency was 53% in hypertensive patients versus 48% in normotensive patients, a difference that was not statistically significant.
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