November 1, 2001Journal of Hypertension
Angiotensinogen genotype and blood pressure response in the Dietary Approaches to Stop Hypertension (DASH) study
Why the study?
Does angiotensinogen genotype affect blood pressure response to the DASH diet in adults with above-optimal blood pressure or stage 1 hypertension?
Population
355 adults with above-optimal blood pressure or stage 1 hypertension
Comparison
DASH diet or 'fruits and vegetables' diet for 8… vs Control diet for 8 weeks
Design
RCT, randomized
Follow-up
8 weeks
Authors
Discussion
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Member takes
Implication
Genotype may inform DASH prioritization for BP control; extends RCT evidence on angiotensinogen as a dietary response modifier.
Structured PICO
Does angiotensinogen genotype affect blood pressure response to the DASH diet in adults with above-optimal blood pressure or stage 1 hypertension?
P
Population
355 adults with above-optimal blood pressure or stage 1 hypertension
I
Intervention
DASH diet (reduced in fats, emphasizing fruits, vegetables, and low-fat dairy products) or 'fruits and vegetables' diet for 8 weeks
C
Comparator
Control diet (similar to typical American intake) for 8 weeks
O
Outcome
Blood pressure after 8 weeks of intervention diet stratified by angiotensinogen (ANG) and ACE genotypessurrogate
The angiotensinogen AA genotype is associated with a significantly greater blood pressure reduction in response to the DASH diet compared to the GG genotype.
Cite This Study
Svetkey et al. (2001) studied this question.