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August 1, 1994American Journal of Hypertension

Frequency of a Deletion Polymorphism in the Gene for Angiotensin Converting Enzyme Is Increased in African-Americans With Hypertension

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Why the study?

Is the frequency of the ACE deletion polymorphism increased in African-Americans with hypertension compared to those with normal blood pressure?

Population

African-Americans

Comparison

Hypertension (cases) vs Normal blood pressure (controls)

Design

Case-control

Authors

KDKenrik DuruUniversity of California, Los AngelesSFStephen FarrowWayne State UniversityJWJiaming WangWuhan Polytechnic University

Discussion

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Implication

Suggests genetic contribution to hypertension risk in African-Americans; hypothesis-generating and requires prospective validation before clinical consideration.

Structured PICO

Is the frequency of the ACE deletion polymorphism increased in African-Americans with hypertension compared to those with normal blood pressure?

P
Population
African-Americans
I
Intervention
Hypertension (cases)
C
Comparator
Normal blood pressure (controls)
O
Outcome
Frequency of the ACE deletion polymorphism

The ACE deletion polymorphism is associated with a higher frequency of hypertension in African-Americans, suggesting a potential genetic contribution to hypertension risk in this population.

Cite This Study

Duru et al. (1994) studied this question.

synapsesocial.com/papers/6a11c7d5a54a38d693fd35ffhttps://doi.org/10.1093/ajh/7.8.759

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin-Converting Enzyme Deletion Polymorphism Is Associated with Hypertension in a Sikh Population1997 · 35 citations
  2. 2Differences in Frequency of the Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene in Different Ethnic Groups2001 · 41 citations
  3. 3Angiotensin I-Converting Enzyme Insertion/Deletion Polymorphism: Clinical Implications1997 · 12 citations
  4. 4Angiotensin I Converting Enzyme Gene Polymorphism in Chinese Patients With Hypertension1997 · 34 citations
  5. 5Promoter Polymorphisms in ACE (Angiotensin I–Converting Enzyme) Associated With Clinical Outcomes in Hypertension2008 · 38 citations