Why the study?
Is the ACE deletion polymorphism associated with hypertension in a Sikh population?
Population
Sikh population, including subjects with hypertension and normotensive controls
Comparison
Presence of the ACE gene deletion polymorphism vs Normotensive subjects
Design
Case-control
Authors
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ACE deletion-hypertension link extends to Sikhs; hypothesis-generating, requires validation before any clinical use.
Is the ACE deletion polymorphism associated with hypertension in a Sikh population?
The ACE deletion polymorphism is significantly associated with hypertension in a Sikh population, suggesting a genetic contribution to hypertension development in this ethnic subgroup.
Mastan et al. (1997) studied this question.
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