Key result
Female sex is linked to ~87% higher atrial tachyarrhythmia recurrence after cryo-PVI for paroxysmal AF.
Why the study?
Literature data on the outcomes of radiofrequency catheter ablation for AF in women are contradictory, prompting comparison of outcomes and complications of cryoballoon pulmonary vein isolation between men and women.
Does female sex increase the risk of atrial tachyarrhythmia recurrence and peri-operative complications in patients undergoing cryoballoon pulmonary vein isolation for symptomatic atrial fibrillation compared to male sex?
Population
733 consecutive patients undergoing cryo-PVI for symptomatic AF (550 men and 183 women)
Comparison
Women vs men undergoing cryoballoon pulmonary vein isolation
Design
Single-center prospective cohort study
Authors
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Female sex associated with higher ATa recurrence after cryo-PVI for paroxysmal AF; leaves open whether sex-specific strategies improve outcomes.
Cohort (n=733)
No
Does female sex increase the risk of atrial tachyarrhythmia recurrence and peri-operative complications in patients undergoing cryoballoon pulmonary vein isolation for symptomatic atrial fibrillation compared to male sex?
Effect estimate: HR 1.87 (95% CI 1.28-2.73)
Absolute Event Rate: 41% vs 27%
p-value: p=0.001
Women undergoing cryoballoon pulmonary vein isolation for paroxysmal atrial fibrillation have significantly higher rates of arrhythmia recurrence and peri-operative complications compared to men.
Hermida et al. (2022) conducted a cohort in Atrial fibrillation (n=733). Female sex (Cryoballoon pulmonary vein isolation) vs. Male sex was evaluated on Recurrence of atrial tachyarrhythmia (ATa) after cryo-PVI for paroxysmal AF (HR 1.87, 95% CI 1.28-2.73, p=0.001). Female sex was an independent predictor of atrial tachyarrhythmia recurrence after cryoballoon pulmonary vein isolation for paroxysmal atrial fibrillation (HR 1.87).
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