What question did this study set out to answer?

Determine the efficacy and safety of endovascular thrombectomy compared to best medical care alone in stroke patients with extended ischemic lesions presenting within a 12-hour window.

August 29, 2018International Journal of StrokeOpen Access

A randomized controlled trial to test efficacy and safety of thrombectomy in stroke with extended lesion and extended time window

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Determine the efficacy and safety of endovascular thrombectomy compared to best medical care alone in stroke patients with extended ischemic lesions presenting within a 12-hour window.
Investigator-initiated, randomized, open-label, blinded-endpoint European adaptive trial (TENSION; NCT03094715) planning to enroll up to 665 patients.
Inclusion criteria specify anterior circulation large vessel occlusion with extended ischemic damage, defined by an Alberta Stroke Program Early Computed Tomography Scan score of 3–5, presenting up to 12 hours from symptom onset or last seen well.
Participants are randomly allocated to receive either endovascular thrombectomy plus best medical care or best medical care alone, with follow-up through 90 days.
The primary efficacy outcome is functional disability measured by the modified Rankin Scale at 90 days post-stroke.
The primary safety outcome evaluates the composite rate of mortality and severe dependency (modified Rankin Scale 4–6) at 90 days.
Secondary analyses evaluate health-related quality of life, adverse events, post-stroke depression, and health economic cost-utility.

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Implication

Randomized trial reports the evaluation of thrombectomy for extended ischemic stroke up to twelve hours post-onset, highlighting potential to expand care for severe stroke cases.

Cite This Study

Bendszus et al. (2018) studied this question.

synapsesocial.com/papers/6a11d72045487b7639a5699e https://doi.org/10.1177/1747493018798558

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Implication

Randomized trial reports the evaluation of thrombectomy for extended ischemic stroke up to twelve hours post-onset, highlighting potential to expand care for severe stroke cases.

A randomized controlled trial to test efficacy and safety of thrombectomy in stroke with extended lesion and extended time window

Key Points

Discussion

Implication

Cite This Study

A randomized controlled trial to test efficacy and safety of thrombectomy in stroke with extended lesion and extended time window

Key Points

Discussion

Implication

Cite This Study

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