What question did this study set out to answer?

This trial aims to evaluate the benefit-risk profile of endovascular therapy conducted within 24 to 72 hours post-stroke onset in patients with acute ischemic stroke.

June 1, 2026International Journal of Stroke

Large Artery occlusion Treated in Extended Time with Mechanical Thrombectomy (LATE-MT): protocol for a multicenter randomized clinical trial

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This trial aims to evaluate the benefit-risk profile of endovascular therapy conducted within 24 to 72 hours post-stroke onset in patients with acute ischemic stroke.
Multicenter, prospective, randomized, open, blinded-endpoint assessment (PROBE) clinical trial design.
336 patients with large-vessel occlusion were recruited across 35 stroke centers in China.
Participants are randomized 1:1 to receive either endovascular therapy or medical management.
Primary outcome is assessed through ordinal shift analysis of modified Rankin scale scores at 90 days.
Key secondary outcomes include neurological function at 24 hours and 7 days, mortality, and utility-weighted modified Rankin scale at 90 days.
Safety outcomes tracked include all instances of intracranial hemorrhage and serious adverse events.

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Implication

Randomized trial examines outcomes of endovascular therapy in acute ischemic stroke up to 72 hours, suggesting potential benefits and risks.

Cite This Study

Shen et al. (2026) studied this question.

synapsesocial.com/papers/6a1d236002fbce9130638f6c https://doi.org/10.1177/17474930261458848

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Implication

Randomized trial examines outcomes of endovascular therapy in acute ischemic stroke up to 72 hours, suggesting potential benefits and risks.

Large Artery occlusion Treated in Extended Time with Mechanical Thrombectomy (LATE-MT): protocol for a multicenter randomized clinical trial

Key Points

Discussion

Implication

Cite This Study

Large Artery occlusion Treated in Extended Time with Mechanical Thrombectomy (LATE-MT): protocol for a multicenter randomized clinical trial

Key Points

Discussion

Implication

Cite This Study

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