What question did this study set out to answer?

To compare the functional outcomes and safety of endovascular thrombectomy versus best medical management for patients with large-vessel occlusion beyond 24 hours of symptom onset.

February 2, 2026Stroke

Abstract DP344: Endovascular Treatment versus Medical Management for Acute Large Vessel Occlusion Beyond 24 Hours.

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Authors

WCWenhuo ChenFujian Medical University TYTing-yu YiFujian Medical University

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Implication

A multicenter cohort study evaluates EVT and BMM outcomes in patients with LVO beyond 24 hours, suggesting improved functional independence with EVT.

Key Points

To compare the functional outcomes and safety of endovascular thrombectomy versus best medical management for patients with large-vessel occlusion beyond 24 hours of symptom onset.
Retrospective multicenter cohort study using stroke registries from 8 comprehensive stroke centers in China.
Included patients with acute ischemic stroke from internal carotid or middle cerebral artery occlusions.
Primary outcome assessed was functional independence at 3 months using the modified Rankin Scale.
Safety outcomes included mortality and symptomatic intracranial hemorrhage, analyzed using IPTW logistic regression.
308 patients were studied, with 205 receiving EVT and 103 receiving BMM.
EVT led to 50.7% achieving functional independence compared to 34.0% in the BMM group (adjusted odds ratio of 2.8).
No significant increase in symptomatic intracranial hemorrhage or mortality was noted with EVT.
Efficacy of EVT diminished as symptom onset to treatment time increased, disappearing past 72.8 hours.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6980fc17c1c9540dea80dd90 https://doi.org/10.1161/str.57.suppl_1.dp344

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Implication

A multicenter cohort study evaluates EVT and BMM outcomes in patients with LVO beyond 24 hours, suggesting improved functional independence with EVT.

Abstract DP344: Endovascular Treatment versus Medical Management for Acute Large Vessel Occlusion Beyond 24 Hours.

Discussion

Member takes

Implication

Key Points

Cite This Study

Abstract DP344: Endovascular Treatment versus Medical Management for Acute Large Vessel Occlusion Beyond 24 Hours.

Discussion

Member takes

Implication

Key Points

Cite This Study

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