Key result
Higher LGE-CMR fibrosis density is linked to slower conduction velocity in ischemic cardiomyopathy.
Why the study?
Characterizing myocardial conduction velocity in patients with ischemic cardiomyopathy and ventricular tachycardia is important for understanding proarrhythmic substrates, but the relation between conduction velocity and fibrosis density on late gadolinium-enhanced cardiac magnetic resonance imaging required accurate assessment.
Is myocardial conduction velocity associated with scar distribution on LGE-CMR in patients with ischemic cardiomyopathy?
Observational (n=11)
Is myocardial conduction velocity associated with scar distribution on LGE-CMR in patients with ischemic cardiomyopathy?
Effect estimate: 1.34-fold decrease per 25% increase in LGE intensity (95% CI 1.25-1.43)
Absolute Event Rate: 0.41% vs 0.65%
Conduction velocity is inversely associated with LGE-CMR fibrosis density in patients with ischemic cardiomyopathy, suggesting noninvasive conduction velocity maps derived from LGE-CMR could improve ventricular tachycardia ablation planning.
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May support LGE-derived conduction velocity estimation in ischemic cardiomyopathy; leaves open utility for ventricular tachycardia ablation planning.
Aronis et al. (2020) conducted an observational in Ischemic cardiomyopathy and ventricular tachycardia (n=11). Late gadolinium-enhanced cardiac magnetic resonance imaging (LGE-CMR) and electroanatomic mapping vs. Controls with structurally normal left ventricles was evaluated on Association between LGE-CMR intensity and conduction velocity (1.34-fold decrease per 25% increase in LGE intensity, 95% CI 1.25-1.43). Conduction velocity was inversely associated with LGE-CMR fibrosis density in patients with ischemic cardiomyopathy, decreasing by 1.34-fold (95% CI, 1.25-1.43) per 25% increase in LGE intensity.
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