Highlights a case of primary systemic amyloidosis causing severe intramural coronary artery occlusion, myocardial infarction, and systemic emboli in the absence of extramural arteriosclerosis.
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Amyloid may underlie intramural coronary occlusion and embolization without extramural disease; hypothesis-generating for prevalence and management.
A patient had primary systemic amyloidosis with severe cardiac involvement and IgG paraproteinemia. Numerous intramural coronary arteries were occluded by amyloid deposits, but arteriosclerosis of the extramural arteries was absent. The amyloid coronary artery disease was associated with angina pectoris, a myocardial infarct, and mural thrombi which resulted in cerebral, renal, pulmonic, and coronary arterial emboli.
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Rolf F. Barth (1970) studied this question.
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