Key result
Stress-precipitated syncope in AL cardiac amyloidosis was associated with higher sudden death (87.5% vs 22.4%) and shorter median survival (2 vs 13 months, P<0.005) compared to nonstress syncope.
Why the study?
Does stress-related syncope predict worse survival in patients with AL cardiac amyloidosis compared to non-stress-related syncope?
Population
26 patients with biopsy-proven systemic AL amyloidosis, cardiac involvement, and a history of ≥1 episodes of…
Design
Cohort
Follow-up
Median survival 2 to 13 months
Authors
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Stress syncope in AL amyloidosis warrants heightened vigilance for sudden death; observational data leaves open optimal risk stratification.
Cohort (n=26)
Does stress-related syncope predict worse survival in patients with AL cardiac amyloidosis compared to non-stress-related syncope?
Absolute Event Rate: 87.5% vs 22.4%
p-value: p=<0.005
Stress-related syncope in AL cardiac amyloidosis is associated with a very high risk of sudden cardiac death and significantly shorter survival compared to other causes of syncope.
Chamarthi et al. (1997) conducted a cohort in AL cardiac amyloidosis with syncope (n=26). Stress-related syncope vs. Nonstress-related syncope was evaluated on Sudden death (p=<0.005). Stress-precipitated syncope in AL cardiac amyloidosis was associated with higher sudden death (87.5% vs 22.4%) and shorter median survival (2 vs 13 months, P<0.005) compared to nonstress syncope.
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