Key result
Severe autonomic neuropathy prevents HF symptoms in cardiac amyloidosis by blunting sympathetic activation.
Why the study?
The essential role of sympathetic activation and venous tone in the development of congestive heart failure syndrome remains unclear despite severe cardiac amyloidosis.
Population
A 66-year-old man with primary light-chain (AL) amyloidosis and severe cardiac involvement
Design
Case report
Authors
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May mask heart failure symptoms in cardiac amyloidosis; hypothesis-generating case requiring prospective validation.
Case Report (n=1)
Abramov et al. (2009) conducted a case report in Primary light-chain (AL) amyloidosis (n=1). Severe autonomic neuropathy was evaluated on Development of congestive heart failure symptoms. A 66-year-old man with severe cardiac amyloidosis did not develop congestive heart failure symptoms due to severe autonomic neuropathy preventing sympathetic activation and venous tone maintenance.
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