Mechanism of Lymphocyte-Mediated Cytotoxicity

Pierre A. Henkart

doi:10.1146/annurev.iy.03.040185.000335

April 1, 1985Annual Review of Immunology

Mechanism of Lymphocyte-Mediated Cytotoxicity

View at Publisher

Ask AI

Bookmark

Share

Key Points

Characterize the biological mechanisms of lymphocyte-mediated cytotoxicity and delineate the molecular pathways driving CD8 T cell exhaustion during chronic antigen exposure.
Evaluated cellular and molecular profiles of cytotoxic CD8 T cells in human and animal models of chronic viral infection and malignancy.
Analyzed functional changes, inhibitory receptor expression patterns, and lineage differentiation paths distinguishing exhausted T cells from effector and memory subsets.
Exhausted CD8 T cells form a distinct developmental lineage characterized by progressive, hierarchical loss of effector functions including cytokine production and cytolytic activity.
Persistent antigen stimulation drives sustained upregulation of multiple inhibitory receptors that actively suppress cytotoxic immune responses.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Scientific review uncovers mechanisms of CD8 T cell exhaustion in chronic infections and cancer, highlighting therapeutic avenues to restore cytotoxicity.

Abstract

No abstract yet. The journal hasn't published one we can show.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Pierre A. Henkart (1985) studied this question.

synapsesocial.com/papers/6a11e4c4a8e383061b8e133c https://doi.org/10.1146/annurev.iy.03.040185.000335

View at Publisher

Ask AI

Bookmark

Share

Mechanism of Lymphocyte-Mediated Cytotoxicity

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Mechanism of Lymphocyte-Mediated Cytotoxicity

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading