The Major Histocompatibility Complex-Restricted Antigen Receptor on T Cells

Kathryn Haskins; John W. Kappler; Philippa Marrack

doi:10.1146/annurev.iy.02.040184.000411

April 1, 1984Annual Review of Immunology

The Major Histocompatibility Complex-Restricted Antigen Receptor on T Cells

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Key Points

The research aims to understand the characteristics and functions of exhausted CD8 T cells during chronic infections and cancers.
Characterization of Tex cells in animal models and humans
Analysis of effector functions and inhibitory receptor expression
Tex cells exhibit a significant loss of effector functions
High expression of inhibitory receptors correlates with chronic infections and cancers
Findings highlight potential targets for immunotherapy

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Implication

Explores the impact of antigen receptors on exhaust CD8 T cells, suggesting new therapeutic strategies.

Abstract

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...

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Cite This Study

Haskins et al. (1984) studied this question.

synapsesocial.com/papers/6a20ebc25496711a5f2ab073 https://doi.org/10.1146/annurev.iy.02.040184.000411

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The Major Histocompatibility Complex-Restricted Antigen Receptor on T Cells

Key Points

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Cite This Study

The Major Histocompatibility Complex-Restricted Antigen Receptor on T Cells

Key Points

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Implication

Abstract

Discussion

Cite This Study

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